TABLE 3.
Top 10 associations (ranked by nominal P values among HA women) between ion channel-related genes and diabetes risk in the WHI-SHARe cohort1
| Minor allele frequency (AA/HA) |
AA women (n = 7287) |
HA women (n = 3285) |
||||||
| Locus | SNP | Major/minor allele | Cases | Controls | OR (95% CI) | P | OR (95% CI) | P (FDR-adjusted P) |
| SLC41A2 | rs10861279 | T/G | 0.08/0.03 | 0.07/0.07 | 1.11 (0.96, 1.28) | 0.17 | 0.54 (0.38, 0.77) | 0.0006 (0.04)* |
| MRS2 | rs7738943 | G/C | 0.13/0.08 | 0.12/0.06 | 1.02 (0.90, 1.14) | 0.79 | 1.55 (1.20, 2.00) | 0.0006 (0.01)* |
| NIPA1 | rs7174119 | G/A | 0.22/0.30 | 0.22/0.27 | 1.00 (0.91, 1.10) | 1.00 | 1.27 (1.10, 1.47) | 0.002 (0.04)* |
| MRS2 | rs1056285 | G/A | 0.14/0.08 | 0.14/0.06 | 1.02 (0.91, 1.14) | 0.74 | 1.48 (1.20, 1.90) | 0.002 (0.02)* |
| FXYD2 | rs479991 | T/C | 0.27/0.19 | 0.28/0.23 | 0.99 (0.91, 1.08) | 0.84 | 0.79(0.67, 0.93) | 0.005 (0.07) |
| NIPA1 | rs6606830 | C/T | 0.21/0.29 | 0.22/0.27 | 1.00 (0.91, 1.10) | 0.94 | 1.23 (1.10, 1.43) | 0.01 (0.07) |
| SLC41A2 | rs11112191 | T/C | 0.27/0.17 | 0.27/0.20 | 1.00 (0.91, 1.09) | 0.96 | 0.78 (0.66, 0.93) | 0.01 (0.15) |
| KCNJ11 | rs1800467 | G/C | 0.01/0.06 | 0.009/0.04 | 1.01 (0.65, 1.55) | 0.98 | 1.49 (1.10, 2.01) | 0.01 (0.11) |
| SLC12A3 | rs8061631 | C/T | 0.38/0.22 | 0.37/0.25 | 1.02 (0.94, 1.11) | 0.62 | 0.81 (0.69, 0.95) | 0.01 (0.32) |
| SLC41A2 | rs11112211 | G/C | 0.09/0.05 | 0.08/0.07 | 1.05 (0.92, 1.21) | 0.47 | 0.67 (0.49, 0.92) | 0.01 (0.15) |
1
n = 10,572. ORs and 95% CIs were computed by using additive model with multivariate logistic regression models and were adjusted for age, region, and 3 principal components of global ancestry. *FDR-adjusted P ≤ 0.05. AA, African American; FDA, false discovery rate; HA, Hispanic American; SHARe, SNP Health Association Resource; SNP, single nucleotide polymorphism WHI, Women’s Health Initiative.