TABLE 4.

Significant associations (FDR q ≤ 0.05) between ion channel-related genes and diabetes risk stratified by total magnesium intake in the WHI-SHARe cohort¹

		AA women				HA women
		Low intake (≤0.164 g/d; n = 2154)		High intake (≥0.291 g/d; n = 2120)		Low intake (≤0.185 g/d; n = 1015)		High intake (≥0.313 g/d; n = 954)
Locus	SNP	OR (95% CI)	P	OR (95% CI)	P (FDR-adjusted P)	OR (95% CI)	P (FDR q)	OR (95% CI)	P (FDR-adjusted P)
KCNJ11	rs1800467	0.97 (0.46, 2.04)	0.93	1.13 (0.55, 2.32)	0.74	1.11 (0.66, 1.86)	0.70	2.50 (1.50, 4.28)	<0.001 (0.01)*
CLDN19	rs11590362	1.24 (0.79, 1.93)	0.34	1.23 (0.80, 1.88)	0.34	2.01 (1.20, 3.37)	0.01 (0.04)**	1.38 (0.79, 2.41)	0.26
SLC41A1	rs823154	1.06 (0.9, 1.26)	0.47	1.02 (0.85, 1.23)	0.84	1.46 (1.10, 1.86)	0.002 (0.04)**	1.01 (0.75, 1.37)	0.93
CNNM1	rs6584273	0.88 (0.74, 1.06)	0.18	0.71 (0.59, 0.87)	<0.001 (0.04)**	0.93 (0.52, 1.66)	0.80	0.88 (0.46, 1.71)	0.71
NIPA2	rs7170784	1.05 (0.88, 1.26)	0.58	0.94 (0.77, 1.13)	0.50	1.07 (0.86, 1.34)	0.55	0.62 (0.47, 0.80)	<0.001 (0.01)**
NIPA2	rs8028189	1.05 (0.88, 1.26)	0.60	0.93 (0.77, 1.13)	0.46	1.08 (0.87, 1.35)	0.48	0.65 (0.50, 0.84)	0.001 (0.01)*
MMGT1	rs5929706	0.89 (0.60, 1.32)	0.57	0.73 (0.47, 1.14)	0.17	4.66 (1.50, 14.3)	0.01 (0.05)**	1.42 (0.29, 6.90)	0.67
MMGT1	rs5930817	1.09 (0.83, 1.43)	0.54	0.90 (0.66, 1.23)	0.52	3.10 (1.40, 6.85)	0.01 (0.05)**	0.88 (0.19, 4.03)	0.87

¹ORs and 95% CIs were computed by using additive model with multivariate logistic regression models and were adjusted for age, region, and 3 principal components of global ancestry. *FDR-adjusted P ≤ 0.01; **FDR-adjusted P ≤ 0.05. AA, African American; FDA, false discovery rate; HA, Hispanic American; SHARe, SNP Health Association Resource; SNP, single nucleotide polymorphism WHI, Women’s Health Initiative.