Multivariable adjusted hazard ratios (HR) for appropriate ICD shocks (left), all-cause mortality (center) and all-cause mortality censored at the first appropriate ICD shock (right) by quartiles of biomarkers of inflammation, neurohumoral activation and myocardial injury. Hazard ratios were adjusted for age, sex, race, study center, smoking status, body mass index, NYHA class, atrial fibrillation, diabetes, hypertension, chronic kidney disease, and CRT device.