Extended Data Figure 2. Motifs.

(a) 32 TF gene families with a binding dataset for at least two species (names abbreviated). Cross enrichment indicates the enrichment of motifs from one species in the datasets of another. For 13 families, we observed no cross enrichment (red). For 7 families (blue) we observed cross enrichment and for an additional 12 (green) we also had matching motifs. For two cases marked by an asterisk a known fly motif matches the human motif but no worm motif matches. (b) PRDM1/Blimp-1/blmp-1 gene family. We discovered a motif in worm datasets that match literature derived known motifs from human and fly. (c) All three motifs are highly similar and enriched in human PRDM1 and worm blmp-1 datasets. Cell-type and treatment are indicated for each dataset in parenthesis. Enrichments in each box are the fraction of motif instances that are inside the bound regions and dividing that by the fraction of shuffled motif instances. Additional motifs known and discovered for these and other datasets are included in Supplementary Information.