Table 2.
Summary of responsiveness data*
| Patient cohort evaluated |
ES | SRM | MCID | |
|---|---|---|---|---|
| Function measures | ||||
| IKDC | Knee injuries (ACL, meniscal, chondral) (20,23) | Meniscal repair/resection (12 m): 2.11 Various cartilage procedures: 0.76 (6 m), 1.06 (12 m) |
Meniscal repair/resection (12 m): 1.5 Various cartilage procedures: 0.57 (6 m), 1.0 (12 m) |
Chondral injuries: 6.3 (6 m), 16.7 (12 m) |
| Cohort of mixed knee pathologies (22,24) | Various surgical procedures (6–28 m): 1.13 | Various surgical procedures: 4.4 (4–8 m), 0.94 (6–28 m) | 6–28 m: 11.5 (sensitive), 20.5 (specific) | |
| KOOS | Knee injuries (25,27,36) | Partial meniscectomy (3 m): 1.11 (pain), 0.93 (symp.), 0.67 (ADL), 0.9 (sport/rec), 1.15 (QOL) ACLR (6 m): 0.84 (pain), 0.87 (symp.), 0.94 (ADL), 1.16 (sport/rec), 1.65 (QOL) ACI, MF (3 y): 0.82 (pain), 0.72 (symp.), 0.7 (ADL), 0.98 (sport/rec), 1.32 (QOL) |
ACI, MF (3 y): 0.71 (pain), 0.61 (symp.), 0.75 (ADL), 0.87 (sport/rec), 0.76 (QOL) | – |
| Knee OA (28,31,33) | PT (4 w): 1.08 (pain), 0.97 (symp.), 1.07 (ADL), 0.79 (sport/rec), 0.78 (QOL) TKR (3 m): 2.59 (pain), 1.63 (symp.), 2.52 (ADL), 1.31 (sport/rec), 2.8 (QOL) TKR (6 m): 2.28 (pain), 1.24 (symp.), 2.25 (ADL), 1.18 (sport/rec), 2.86 (QOL) TKR (12 m): 2.55 (pain), 1.59 (symp.), 2.56 (ADL), 1.08 (sport/rec), 3.54 (QOL) |
PT (4 w): 1.28 (pain), 1.02 (symp.), 1.37 (ADL), 0.83 (sport/rec), 0.87 (QOL) TKR (3 m): 1.85 (pain), 1.45 (symp.), 1.8 (ADL), 0.89 (sport/rec), 1.93 (QOL) TKR (6 m): 1.67 (pain), 0.99 (symp.), 1.7 (ADL), 0.81 (sport/rec), 1.6 (QOL) TKR (12 m): 2.12 (pain), 1.25 (symp.), 1.9 (ADL), 0.88 (sport/rec), 1.99 (QOL) |
– | |
| KOOS-PS | Knee OA (40–42) | PT (4 w): 0.5–0.88 HAI (4 w): 0.51 |
PT (4 w): 0.73–1.21 HAI (4 w): 0.8 TKR (6 m): 1.4 |
– |
| KOS-ADL | Mixed knee pathologies (43,45–47) | PT: 0.44 (1 w), 0.94 (4 w), 1.26 (8 w) PT (6 w): 0.63 TKR (6 m): 1.3 |
PT (6 w): 7.1 TKR (6 m): 1.1 |
PFPS: 7.1 |
| Lysholm Knee Scoring Scale | Knee injuries (ACL, meniscal, chondral; patellar dislocation) (55,61,63) | ACLR: 1.0 (6–9 m), 1.1 (1–2 y) Meniscal repair (1 y): 1.2 MF (1–6 y): 1.2 |
ACLR: 0.93 (6 m), 1.1 (9 m), 1.2 (1 y), 0.93 (2 y) Meniscal repair (1 y): 0.97–1.13 MF (1–6 y): 1.1 |
– |
| Mixed knee pathologies (47,62,120) | PT (1 m): 0.9 | Variety of nonsurgical and surgical interventions (3 m): 0.9 | – | |
| OKS | Knee OA (46,66) | TKR (6 m): 0.9–2.19 | TKR (6 m): 0.7 | – |
| WOMAC | Chondral defects (23) | Various cartilage surgeries (6 m): 0.98 (pain), 0.51 (symp.), 0.88 (function) Various cartilage surgeries (12 m): 1.14 (pain), 0.72 (symp.), 1.2 (function) |
Various cartilage surgeries (6 m): 0.91 (pain), 0.40 (symp.), 0.86 (function) Various cartilage surgeries (12 m): 0.94 (pain), 0.64 (symp.), 1.13 (function) |
– |
| Knee OA (42,46,92, 96,97,100,101,105, 106,108,124–128) | TKR (3 m): 1.62 (pain), 1.26 (symp.), 2.02 (function) TKR (6 m): 0.95–1.9 (pain), 0.88–1.5 (symp.), 1.01–2.2 (function) TKR (1 y): 1.8–2.4 (pain), 1.8–3.1 (function) TKR (2 y): 1.9–41 (pain), 1.3–24 (symp.), 1.7–23.9 (function) Exercise (2 w): 0.74–0.88 (pain), 0.32–0.44 (symp.), 0.50–0.79 (function) Exercise (6 m): 0.41 (pain), 0.28 (function) Rehabilitation (not defined): 0.52 (pain), 0.42 (symp.), 0.44 (function) Drug (2 w): 0.94 (pain), 0.46 (symp.), 0.72 (function) Drug (3 w): 0.76–0.88 (pain), 0.59–0.63 (symp.), 0.75–0.77 (function) Drug (4 w): 0.69 (pain), 0.41 (symp.), 0.56 (function) Drug (6 w): 0.53–0.8 (pain), 0.6–0.75 (symp.), 0.58–0.82 (function) Drug (8 w): 0.58 (pain), 0.53 (symp.), 0.76 (function) Drug (12 w): 0.44–0.91 (pain), 0.55–0.84 (symp.), 0.58–0.81 (function) Acupuncture (3 w): 0.4 (pain), 0.52 (symp.), 0.31 (function) Acupuncture (8 w): 1.3 (pain), 1.2 (function) |
TKR (3 m): 1.14–1.58 (pain), 1.15 (symp.), 1.02–2.02 (function) TKR (6 m): 0.95–1.8 (pain), 0.63–1.3 (symp.), 0.9–1.9 (function) TKR (2 y): 1.55 (pain), 1.03 (symp.), 1.32 (function) Drug (2 w): 1.09 (pain), 0.43 (symp.), 0.89 (function) Exercise (2 w): 0.78–1 (pain), 0.29–0.52 (symp.), 0.69–0.94 (function) |
NSAIDs (4 w, function): 9.1 (absolute), 26 (relative) TKR (6 m): 22.87 (pain), 14.43 (symp.), 19.01 (function) TKR (12 m): 36 (pain), 33 (function) TKR (2 y): 27.98 (pain), 21.35 (symp.), 20.84 (function) |
|
| Activity measures | ||||
| ARS | Baseline knee athletic activity for cohort of mixed knee pathologies | – | – | – |
| TAS | Knee injuries (ACL, meniscal; patellar dislocation) (55,61) | Various meniscal surgeries (12 m): 0.61 (isolated lesions), 0.84 (combined lesions) ACLR: 0.74 (6 m), 1.1 (9 m), 1.0 (1 y), 1.0 (2 y) |
Various meniscal surgeries (12 m): 0.6 (isolated lesions), 0.7 (combined lesions) ACLR: 0.61 (6 m), 0.84 (9 m), 0.96 (1 y), 1.0 (2 y) |
– |
| Knee OA | – | – | – | |
*
ES = effect size; SRM = standardized response mean; MCID = minimum clinically important difference; IKDC = International Knee Documentation Committee Subjective Knee Evaluation Form; ACL = anterior cruciate ligament; KOOS = Knee Injury and Osteoarthritis Outcome Score; symp. = symptoms; ADL = activities of daily living; sport/rec = sport/recreation; QOL = quality of life; ACLR = ACL reconstruction; ACI = autologous chondrocyte implantation; MF = microfracture; OA = osteoarthritis; PT = physical therapy; TKR = total knee replacement; KOOS-PS = Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form; HAI = intraarticular hyaluronic acid injection; KOS-ADL = Knee Outcome Survey Activities of Daily Living Scale; PFPS = patellofemoral pain syndrome; OKS = Oxford Knee Score; WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index; NSAIDs = nonsteroidal antiinflammatory drugs; ARS = Activity Rating Scale; TAS = Tegner Activity Scale.