Table 2.
US FDA-approved drugs with package inserts containing pharmacogenetics and pharmacogenomics information.
| Drug | Disease type | Pharmacogenomic biomarker(s) |
|---|---|---|
| Abacavir | Infectious diseases | HLA-B |
| Amitriptyline | Psychiatry | CYP2D6 |
| Aripiprazole | Psychiatry | CYP2D6 |
| Atomoxetine | Psychiatry | CYP2D6 |
| Atorvastatin | Endocrinology | LDLR |
| Azathioprine | Rheumatology | TPMT |
| Belimumab | Autoimmune diseases | BTG3 |
| Boceprevir | Infectious diseases | IFNL3 |
| Carbamazepine | Neurology | HLA-B, HLA-A |
| Carglumic acid | Metabolic disorders | NAGS |
| Carisoprodol | Rheumatology | CYP2C19 |
| Carvedilol | Cardiology | CYP2D6 |
| Celecoxib | Rheumatology | CYP2C9 |
| Cevimeline | Dermatology | CYP2D6 |
| Chloroquine | Infectious diseases | G6PD |
| Chlorpropamide | Endocrinology | G6PD |
| Citalopram | Psychiatry | CYP2C19, CYP2D6 |
| Clobazam | Neurology | CYP2C19 |
| Clomipramine | Psychiatry | CYP2D6 |
| Clopidogrel | Cardiology | CYP2C19 |
| Clozapine | Psychiatry | CYP2D6 |
| Codeine | Anesthesiology | CYP2D6 |
| Dapsone | Dermatology, infectious diseases | G6PD |
| Desipramine | Psychiatry | CYP2D6 |
| Dexlansoprazole | Gastroenterology | CYP2C19, CYP1A2 |
| Dextromethorphan and quinidine | Neurology | CYP2D6 |
| Diazepam | Psychiatry | CYP2C19 |
| Doxepin | Psychiatry | CYP2D6 |
| Drospirenone and ethinyl estradiol | Neurology | CYP2C19 |
| Eltrombopag | Hematology | F5, SERPINC1 |
| Esomeprazole | Gastroenterology | CYP2C19 |
| Fluorouracil | Dermatology | DPYD |
| Fluoxetine | Psychiatry | CYP2D6 |
| Flurbiprofen | Rheumatology | CYP2C9 |
| Fluvoxamine | Psychiatry | CYP2D6 |
| Galantamine | Neurology | CYP2D6 |
| Glimepiride | Endocrinology | G6PD |
| Glipizide | Endocrinology | G6PD |
| Glyburide | Endocrinology | G6PD |
| Iloperidone | Psychiatry | CYP2D6 |
| Imipramine | Psychiatry | CYP2D6 |
| Indacaterol | Pulmonary | UGT1A1 |
| Isosorbide and hydralazine | Cardiology | NAT1–2 |
| Ivacaftor | Pulmonary | CFTR |
| Lansoprazole | Gastroenterology | CYP2C19 |
| Lenalidomide | Hematology | del (5q) |
| Lomitapide | Endocrinology | LDLR |
| Mafenide | Infectious diseases | G6PD |
| Maraviroc | Infectious diseases | CCR5 |
| Methylene blue | Hematology | G6PD |
| Metoclopramide | Gastroentrology | CYB5R1–4 |
| Metoprolol | Cardiology | CYP2D6 |
| Mipomersen | Endocrinology | LDLR |
| Modafinil | Psychiatry | CYP2D6 |
| Mycophenolic acid | Transplantation | HPRT1 |
| Nalidixic acid | Infectious diseases | G6PD |
| Nefazodone | Psychiatry | CYP2D6 |
| Nitrofurantoin | Infectious diseases | G6PD |
| Nortriptyline | Psychiatry | CYP2D6 |
| Omeprazole | Gastroenterology | CYP2C19 |
| Pantoprazole | Gastroenterology | CYP2C19 |
| Paroxetine | Psychiatry | CYP2D6 |
| PEG-3350 | Gastroenterology | G6PD |
| Peginterferon alfa-2b | Infectious diseases | IFNL3 |
| Pegloticase | Rheumatology | G6PD |
| Perphenazine | Psychiatry | CYP2D6 |
| Phenytoin | Neurology | HLA-B |
| Pimozide | Psychiatry | CYP2D6 |
| Prasugrel | Cardiology | CYP2C19 |
| Pravastatin | Endocrinology | LDLR |
| Primaquine | Infectious diseases | G6PD |
| Propafenone | Cardiology | CYP2D6 |
| Propranolol | Cardiology | CYP2D6 |
| Protriptyline | Psychiatry | CYP2D6 |
| Quinidine | Cardiology | CYP2D6 |
| Quinine sulfate | Infectious diseases | G6PD |
| Rabeprazole | Gastroenterology | CYP2C19 |
| Rifampin, isoniazid and pyrazinamide | Infectious diseases | NAT1–2 |
| Risperidone | Psychiatry | CYP2D6 |
| Rosuvastatin | Endocrinology | LDLR |
| Simeprevir | Infectious diseases | IFNL3 |
| Sodium nitrite | Antidotal therapy | G6PD |
| Sofosbuvir | Infectious diseases | IFNL3 |
| Succimer | Hematology | G6PD |
| Sulfamethoxazole and trimethoprim | Infectious diseases | G6PD |
| Telaprevir | Infectious diseases | IFNL3 |
| Terbinafine | Infectious diseases | CYP2D6 |
| Tetrabenazine | Neurology | CYP2D6 |
| Thioridazine | Psychiatry | CYP2D6 |
| Ticagrelor | Cardiology | CYP2C19 |
| Tolterodine | Genitourinary | CYP2D6 |
| Tramadol | Analgesic | CYP2D6 |
| Trimipramine | Psychiatry | CYP2D6 |
| Valproic acid | Neurology | POLG, NAGS, CPS1, ASS1, OTC, ASL, ABL2 |
| Velaglucerase alfa | Metabolic disorders | GBA |
| Venlafaxine | Psychiatry | CYP2D6 |
| Voriconazole | Infectious diseases | CYP2C19 |
| Vortioxetine | Neurology | CYP2D6 |
| Warfarin | Cardiology, hematology | CYP2C9, VKORC1, PROC |
F2: Prothrombin; F5: Factor V Leiden.
Data taken from [32].