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. Author manuscript; available in PMC: 2016 Mar 6.
Published in final edited form as: Eur J Med Chem. 2014 Dec 19;92:64–77. doi: 10.1016/j.ejmech.2014.12.033

Figure 5.

Figure 5

The effect of intrathecal (i.t.) administration of following compounds in CCI neuropathic pain model in rats: morphine (M, 0.35-35 nmol), hybrid 22 (0.1-1 nmol), its parent compound 33 (0.001-1 nmol), hybrid 4 (0.1-1 nmol), its parent compound 7 (0.001-1 nmol) and NK-1 antagonist 6 (0.1 - 1 nmol) on (A) allodynia as measured by von Frey test and (B) on hyperalgesia as measured by cold plate test (6-12 animals per group). Both tests were made on day 7 after injury in CCI-subjected rats. V = vehicle-treated CCI-exposed rats, black bars = toxic effect. Inter-group differences were analyzed by ANOVA Bonferroni's Multiple Comparison Test; *p<0.05, **p<0.01, ***p<0.001 vs. V-treated CCI-exposed rats.