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. Author manuscript; available in PMC: 2016 Mar 6.
Published in final edited form as: Eur J Med Chem. 2014 Dec 19;92:64–77. doi: 10.1016/j.ejmech.2014.12.033

Table 2.

Calculated ED50 values for effect of hybrids 4 and 22 compared to morphine (M) in acute pain (tail-flick test) and neuropathic pain (von Frey and cold plate tests) as measured on naïve rats (acute pain) and neuropathic pain model at day 7 after CCI.

Response (ED50) with 95% confidence limits [nmol i.t.]
ACUTE PAIN NEUROPATHIC PAIN
DRUGS Tail-flick von Frey Cold plate
M 0.49 (0.27-0.89) 6.25 (2.0 - 19.44) 377 (130 - 1093)
4 1.66 (1.11-2.51) 1.05 (0.65 - 1.69) 1.14 (0.74 - 1.77)
22 2.78 (1.80-4.30) 0.24 (0.18 - 0.32) 0.34 (0.25 - 0.46)