Table 1.

Neuropsychological Protocol

Domain	Test	Range	NC**			MCI**
			Baseline	Last Visit†	p-value	Baseline	Last Visit†	p-value
Global Cognition	Mini-Mental State Examination (MMSE) [52]	0–30	28.9±1.4	28.5±2.2	<0.001	26.9±2.6	24.3±5.3	<0.001
Attention	Digit Span Forward [53]	0–12	8.5±2.1	8.4±2.0	<0.001	7.7±2.1	7.5±2.2	<0.001
Information Processing Speed	Digit Symbol [53]	0–93	47.4±12.5	46.0±14.0	<0.001	37.2±12.3	32.5±14.4	<0.001
	Trail Making Test Part A* [54]	0–150	34.8±16.3	36.6±20.1	<0.001	45.3±23.5	55.7±35.0	<0.001
Executive Functioning	Trail Making Test Part B* [54]	0–300	91.4±50.9	102±64.2	<0.001	142.5±77.6	168.7±89.4	<0.001
	Digit Span Backward [53]	0–12	6.8+2.3	6.7+2.3	<0.001	5.7+2.1	5.2+2.2	<0.001
Language	Boston Naming Test-30 Item (BNT-30) [55]	0–30	26.9±3.4	26.9±4.0	0.073	24.1±5.1	22.5±6.6	<0.001
	Animal Naming (Animals) [56]	n/a	20.0±5.7	19.3±6.1	<0.001	15.5±4.9	13.4±5.7	<0.001
	Vegetable Naming (Vegetables) [57]	n/a	14.8±4.2	14.1±4.7	<0.001	11.0±3.9	9.3±4.6	<0.001
Episodic Memory	Logical Memory Immediate Recall [53]	0–25	13.5±3.9	14.1±4.5	<0.001	8.9±4.2	7.7±5.1	<0.001
	Logical Memory Delayed Recall [53]	0–25	12.2±4.2	13.1±5.0	<0.001	6.4±4.6	5.7±5.4	<0.001

Note.

^*lower scores denote better performance;

^**NC and MCI groups differ on all measures at baseline and last visit; p-values reflect within group changes from baseline to last visit;

^†for descriptive purposes only, the difference between last visit and baseline visit cognitive performance was compared; for hypothesis testing, generalized linear mixed models included neuropsychological data across all visits between the first and most recent (last) visit