Table 6.
Categorical FSRP and Longitudinal Cognitive Outcomes
| NC | Q2* | Q3* | Q4* | ||||||
|---|---|---|---|---|---|---|---|---|---|
| β | 95% CI | p-value | β | 95% CI | p-value | β | 95% CI | p-value | |
| Mini-Mental State Exam | −0.07 | −0.10, −0.03 | <0.001 | −0.08 | −0.12, −0.05 | <0.001 | −0.19 | −0.23, −0.15 | <0.001 |
| Digit Span Forward | −0.02 | −0.05, 0.004 | 0.11 | −0.03 | −0.06, 0.00 | 0.031 | −0.05 | −0.08, −0.02 | 0.001 |
| Digit Span Backward | −0.05 | −0.07, −0.02 | <0.001 | −0.06 | −0.09, −0.03 | <0.001 | −0.09 | −0.12, −0.06 | <0.001 |
| Digit Symbol Coding | −0.37 | −0.49, −0.24 | <0.001 | −0.58 | −0.72, −0.45 | <0.001 | −0.85 | −0.99, −0.71 | <0.001 |
| Trail Making Test Part A (log)** | 0.01 | 0.01, 0.02 | <0.001 | 0.02 | 0.01, 0.02 | <0.001 | 0.02 | 0.02, 0.03 | <0.001 |
| Trail Making Test Part B (log)** | 0.01 | 0.01, 0.02 | <0.001 | 0.02 | 0.01, 0.02 | <0.001 | 0.02 | 0.02, 0.03 | <0.001 |
| Animal Naming | −0.14 | −0.21, −0.06 | <0.001 | −0.22 | −0.30, −0.14 | <0.001 | −0.30 | −0.39, −0.22 | <0.001 |
| Vegetable Naming | −0.11 | −0.17, −0.05 | <0.001 | −0.18 | −0.25, −0.12 | <0.001 | −0.22 | −0.29, −0.15 | <0.001 |
| Boston Naming Test-30 Item | −0.04 | −0.09, 0.003 | 0.06 | −0.11 | −0.16, −0.06 | <0.001 | −0.23 | −0.28, −0.17 | <0.001 |
| Logical Memory Immediate Recall | −0.09 | −0.15, −0.03 | 0.01 | −0.21 | −0.28, −0.14 | <0.001 | −0.29 | −0.36, −0.22 | <0.001 |
| Logical Memory Delayed Recall | −0.13 | −0.20, −0.06 | <0.001 | −0.26 | −0.34, −0.19 | <0.001 | −0.36 | −0.43, −0.28 | <0.001 |
| MCI | Q2* | Q3* | Q4* | ||||||
| β | [95% CI] | p-value | β | [95% CI] | p-value | β | [95% CI] | p-value | |
| Mini-Mental State Exam | −0.26 | −0.45, −0.07 | 0.01 | −0.12 | −0.32, 0.08 | 0.24 | −0.07 | −0.28, 0.14 | 0.52 |
| Digit Span Forward | 0.11 | 0.05, 0.17 | <0.001 | 0.05 | −0.02, 0.11 | 0.14 | 0.07 | 0.01, 0.14 | 0.04 |
| Digit Span Backward | 0.09 | 0.02, 0.16 | 0.01 | 0.08 | 0.01, 0.15 | 0.03 | 0.04 | −0.04, 0.11 | 0.32 |
| Digit Symbol Coding | −0.004 | −0.43, 0.42 | 0.99 | 0.29 | −0.16, 0.74 | 0.21 | 0.27 | −0.19, 0.74 | 0.25 |
| Trail Making Test Part A (log)** | 0.002 | −0.01, 0.02 | 0.86 | −0.004 | −0.02, 0.01 | 0.69 | 0.001 | −0.02, 0.02 | 0.88 |
| Trail Making Test Part B (log)** | 0.01 | −0.01, 0.03 | 0.23 | 0.01 | −0.01, 0.03 | 0.31 | 0.01 | −0.01, 0.03 | 0.21 |
| Animal Naming | 0.04 | −0.15, 0.23 | 0.70 | 0.07 | −0.13, 0.27 | 0.48 | 0.11 | −0.10, 0.31 | 0.30 |
| Vegetable Naming | −0.04 | −0.19, 0.11 | 0.58 | −0.05 | −0.20, 0.11 | 0.57 | −0.09 | −0.25, 0.08 | 0.30 |
| Boston Naming Test-30 Item | −0.18 | −0.38, 0.02 | 0.07 | −0.09 | −0.30, 0.12 | 0.40 | −0.03 | −0.24, 0.18 | 0.80 |
| Logical Memory Immediate Recall | −0.12 | −0.28, 0.03 | 0.12 | −0.13 | −0.30, 0.03 | 0.11 | −0.08 | −0.25, 0.09 | 0.37 |
| Logical Memory Delayed Recall | −0.2 | −0.36, −0.05 | 0.01 | −0.14 | −0.31, 0.02 | 0.08 | −0.26 | −0.42, −0.09 | 0.003 |
Note: Data presented as interaction term (time to follow-up*FSRP quartile);
CI=confidence interval;
*
referent=Q1;
**
positive values denote worse performance