Figure 3. In skin, METRNL is expressed in IFNγ-treated keratinocytes and is associated with several skin disorders.

(A) Analysis of METRNL expression in various human diseases indicates strong over-expression in psoriasis (p<0.002)
(B) Comparison of METRNL expression in human keratinocytes, fibroblasts, PBMC and endothelial cells indicate that the highest levels are expressed by fibrobasts.
(C) Human keratinocytes were cultured with a range of activating agents prior to measuring METRNL expression levels. METRNL expression was highest in IFNγ-induced keratinocytes.