Table 1.
Baseline Characteristics
| Characteristic | Acetaminophen n = 18 |
Placebo n = 22 |
|
|---|---|---|---|
| Age (years) | 50 (41 – 64) | 58 (47 – 63) | |
| Men (n, %) | 9 (50%) | 12 (54.5%) | |
| White Race (n, %) | 17 (94.4%) | 19 (86.4%) | |
| APACHE II score | 21 (15.7 – 29) | 22 (16.5 – 24.2) | |
| SOFA score | 5.5 (4 – 8.5) | 6 (5 – 8) | |
| Severe Sepsis Organ Failures | |||
| Cardiovascular | 10 (55.6%) | 16 (72.7%) | |
| Renal | 14 (77.8%) | 17 (77.3%) | |
| Respiratory | 8 (44.4%) | 9 (40.9%) | |
| Hematologic | 3 (16.7%) | 3 (13.6%) | |
| Metabolic | 9 (50%) | 11 (50%) | |
| Source of Severe Sepsis | |||
| Respiratory | 10 (55.6%) | 9 (40.9%) | |
| Urinary | 6 (33.3%) | 6 (27.3%) | |
| Skin | 1 (5.6%) | 1 (4.5%) | |
| Abdominal | 3 (16.7%) | 4 (18.2%) | |
| Central Nervous System | 0 | 1 (4.5%) | |
| Vascular Catheter/Bloodstream | 3 (16.6%) | 4 (18.1%) | |
| Vasoactive Medications (n, %) | 8 (44.4%) | 10 (45.5%) | |
| Mechanical Ventilation | |||
| Invasive (n, %) | 8 (44.4%) | 6 (27.3%) | |
| Non-invasive (n, %) | 1 (5.6%) | 1 (4.5%) | |
| ARDS (n, %) | 5 (27.8%) | 7 (31.8%) | |
| Cell-free Hemoglobin (mg/dl) | 10 (10 – 30) | 20 (10 – 32) | |
| Maximum Temperature (°C) | 37.7 (37 – 38.5) | 37.9 (37.2 – 38.4) | |
| Lactic Acid (mEq/L) (n = 33) | 1.75 (1.22 – 3.25) | 1.8 (1 – 3.75) | |
| AST (U/L) (n = 35) | 38 (24.5 – 59.5) | 41 (24 – 67) | |
| ALT (U/L) (n = 35) | 31.5 (18 – 53.7) | 34 (18.5 – 45.5) | |
| Creatinine (mg/dL) | 1.63 (0.8 – 2.75) | 2.06 (1.02 – 3.59) | |
| F2-Isoprostanes (pg/mL) | 33 (24 – 43) | 40 (29 – 61) | |
| F2-Isofurans (pg/mL) | 45 (34 – 82) | 56 (31 – 94) | |
Data given as median (25th percentile – 75th percentile) or number (percentage) of patients
APACHE = acute physiology and chronic health evaluation; SOFA = sequential organ failure assessment; ARDS = acute respiratory distress syndrome; AST = aspartate aminotransferase; ALT = alanine aminotransferase