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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Dec 12;1849(3):342–352. doi: 10.1016/j.bbagrm.2014.12.009

Figure 2. In the colonic epithelial cell lines and in the ARSB-null mice, BMP4 expression was reduced when ARSB was silenced.

Figure 2

A. Silencing ARSB significantly reduced the expression of BMP4 in the NCM460 cells (p<0.001, one-way ANOVA with Tukey-Kramer post-test; n=6).

B. Similarly, in HT-29 cells, the BMP4 expression was markedly reduced when ARSB was silenced cells (p<0.001, one-way ANOVA with Tukey-Kramer post-test; n=6).

C. In the ARSB null mice, BMP4 mRNA was significantly less than in the control wild-type mice (p=0.011 for female mice, p=0.0341 for male mice; unpaired t-test, two-tailed; n=6).

[ARSB=arylsulfatase B; BMP4=bone morphogenetic protein; F=female; M=male; si-=small interfering siRNA]