Table 3. Effect of Histone H4 Mutations on Proteins Involved in DPCs with 4₈₉.

	% of DNA–protein cross-linksa
histone H4 variant	H2A/H2B	H3	H4
WT	0.6 ± 0.8	6.9 ± 0.1	92.6 ± 0.9
K16A, K20A	0	0	100
K5A, K8A, K12A	0	5.5 ± 2.7	94.7 ± 3.8
H18A	3.2 ± 1.8	10.2 ± 4.5	86.7 ± 6.2
K5R, K8R, K12R, K16R, K20R	3.7 ± 1.3	10.9 ± 0.6	85.4 ± 1.8
K5R, K8R, K12R, K16R, K20R, H18A	19.5 ± 7.1	63.3 ± 5.2	17.3 ± 1.9
H4 deletion	0	100	0

^aValues are the average of three independent reactions ± SD.