Fig. 3.

In contrast to clozapine, which inhibited PCP-induced hyperactivity (b) at a dose lower than that producing sedation (a), ACPC affected neither spontaneous activity (c) nor PCP-induced hyperactivity (d). Values represent the mean (±SEM) distance traveled, expressed as the area under the curve (AUC), in centimeter. Spontaneous activity was measured for the first 30 min following drug administration. PCP-induced hyperactivity was also measured for 30 min, starting 15 min after PCP administration. **P < 0.01 vs. vehicle control, #P < 0.05 vs. PCP. N = 8–9 rats per dose (clozapine study) and 8–16 rats per dose (ACPC study)