Table 6.
Neurodevelopmental assessment according to anti-malarial drug exposure during first trimester
| Exposure group | |||||
|---|---|---|---|---|---|
| AL only | AL and SP | SP and/or quinine | No anti-malarial | Unknown anti-malarial | |
| 14 weeks after delivery | N=81, Median (range) | N=3, Median (range) | N=48, Median (range) | N=367, Median (range) | N=22, Median (range) |
| Motor milestones | 9.0 | 12.0 | 7.0 | 9.0 | 11.5 |
| (6.0-18.0) | (12.0-13.0) | (5.0-37.0) | (2.0-18.0) | (6.0-24.0) | |
| Coordination | 5.0 | 10.0 | 5.0 | 6.0 | 6.0 |
| (4.0-20.0) | (5.0-11.0) | (4.0-34.0) | (2.0-21.0) | (6.0-6.0) | |
| Tone | 18.0 | 18.0 | 18.0 | 18.0 | 17.5 |
| (15.0-23.0) | (17.0-19.0) | (16.0-20.0) | (13.0-24.0) | (14.0-23.0) | |
| Behaviour | 15.0 | 15.0 | 15.0 | 15.0 | 15 |
| (12.0-15.0) | (15.0-15.0) | (10.0-15.0) | (10.0-15.0) | (12.0-15.0) | |
| 14 weeks after delivery | N=81, Mean (SD) | N=3, Mean (SD) | N=48, Mean (SD) | N=367, Mean (SD) | N=22, Mean (SD) |
| Height (cm) | 59.9 (4.11) | 59.6 (4.13) | 59.2 (4.17) | 59.6 (4.15) | 59.8 (4.12) |
| Weight (kg) | 6.7 (0.94) | 6.6 (0.99) | 6.6 (0.93) | 6.6 (0.93) | 6.6 (0.98) |
| One year after delivery | N=75, Median (range) | N=3, Median (range) | N=49, Median (range) | N=365, Median (range) | N=20, Median (range) |
| Motor milestones | 35.0 | 35.0 | 34.0 | 35.0 | 35.0 |
| (25.0-37.0) | (31.0-37.0) | (25.0-37.0) | (20.0-37.0) | (28.0-37.0) | |
| Coordination | 32.0 | 26.0 | 32.0 | 32.0 | 31.0 |
| (19.0-34.0) | (26.0-32.0) | (5.0-33.0) | (12.0-34.0) | (21.0-33.0) | |
| Tone | 20.0 | 18.0 | 19.0 | 20.0 | 18.0 |
| (16.0-20.0) | (17.0-20.0) | (16.0-20.0) | (15.0-24.0) | (16.0-24.0) | |
| Behaviour | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 |
| (12.0-15.0) | (15.0-15.0) | (7.0-15.0) | (9.0-15.0) | (13.0-15.0) | |
| One year after delivery | N=75, Mean (SD) | N=3, Mean (SD) | N=49, Mean (SD) | N=365, Mean (SD) | N=20, Mean (SD) |
| Height (cm) | 70.5 (6.46) | 69.0 (6.32) | 68.9 (6.22) | 70.0 (6.43) | 69.0 (6.35) |
| Weight (kg) | 9.5 (1.08) | 9.4 (1.08) | 9.4 (1.09) | 9.3 (1.09) | 9.4 (1.08) |
Neurodevelopmental assessment done in only 60% of all study participants.