Table 2.
Transcriptomics analysis by IPA showed the up-regulation of several genes in ECs Mes that are involved in EMT/EndMT processes some of which are listed in the table
| Gene name | Function | Fold change | Refs |
|---|---|---|---|
| S100A4 (FSP1) | Mesenchymal marker | +2.54 | [1,17,18] |
| Jagged1 | Notch signaling ligand | +2.31 | [32-34] |
| Notch2 | Jagged1 receptor | +2.12 | [32-34] |
| HEY1 | Notch effector | +2.64 | [62,63] |
| HES4 | Notch effector | +2.1 | [62,63] |
| TGFBI | Involvement in EMT | +2.93 | [18,30,31,34] |
| BMPR1A | TGFβ/Smad receptor | +2.80 | [34,35] |
| EGFR | EMT inducer | +3.78 | [64,65] |
| WNT5B | EMT inducer | +2.23 | [66-68] |
| HMGA2 | EMT-inducing transcribtion factor | +2.13 | [69-71] |
| IGFBP2 | EMT-inducing signaling | +13.12 | [72,73] |
| STAT2 | EMT-inducing signaling | +3.1 | [72,74] |