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. Author manuscript; available in PMC: 2015 Apr 15.
Published in final edited form as: Arch Biochem Biophys. 2014 Mar 13;548:74–85. doi: 10.1016/j.abb.2014.02.014

Fig. 5. Linear free-energy relationship of substituted benzoic acid hydrazide compounds tested on inactivation of Compound I.

Fig. 5

A, Correlation of the log of overall inhibitory rate constant (Ki) for the compounds tested with their respective Hammett's constants (σ). A positive value of σ indicates electron-withdrawing group and a negative value an electron-donating group. B, Correlation of the log of the half maximal inhibitory concentration (IC50) versus σ. C, Correlation of Log(Ki) versus hydrophobicity parameters. Titrations were performed and analyzed as described under “Experimental Procedures.”