Table 3.

Profile of IC₅₀ values for MPO inhibition. Inhibition of MPO activity (%) was determined from progress curves for resorufin generation by mixtures of MPO (23 nM) with ADHP (40 μM) initiated with H₂O₂ (22 μM) in the presence of varied concentrations of 2-ABAH, 4-ABAH, 3-DMABM, NaN₃, 4-FBAH, BAH, 4-NBAH, 4-TFMBH and Isoniazid. Columns presented are abbreviate compound names (inhibitor), compound structure with varied R groups shown in red, and 50% inhibitory concentration with standard error of the mean (IC₅₀ ± SEM).

Inhibitor	Structure	IC50 ± SEM (μM)
2-ABAH		0.50 ± 0.03
4-ABAH		0.71 ± 0.01
3-DMABAH		1.27 ± 0.07
NaN3		6.57 ± 0.32
4-FBAH		22.45 ± 2.19
BAH		40.83 ± 4.00
4-NBAH		54.62 ± 14.06
4-TFMBAH		142.70 ± 10.98
Isoniazid		277.10 ± 6.65