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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Mol Cancer Res. 2014 Sep 24;13(2):231–238. doi: 10.1158/1541-7786.MCR-14-0481-T

Figure 1. ErbB2-initiatedearly lesions in p53-null mammary glands exhibit decreased senescence but intact apoptosis.

Figure 1

Lentivirus was used to carry caErbB2 into the mammary glands. Early lesions were analyzed two weeks following viral injection. Scale bar = 20μm. For bar graphs, columns represent the mean, and error bars represent the SEM.

A. H&E of premalignant lesions from wildtype and p53-null mammary glands.

B. Quantification of macroH2A-positive cells in premalignant lesions from widltype and p53-null mice (n=3, 4). Representative images shown.

C. Quantification of p16-positive cells in premalignant lesions from widltype and p53-null mice (n=4, 5). Representative images shown.

D. Quantification of TUNEL-positive cells (red) in premalignant lesions from widltype and p53-null mice (n=4). Representative images shown.

E. Quantification of CC3-positive cells (red) in premalignant lesions from widltype and p53-null mice (n=3,4). Representative images shown.