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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Mol Cancer Res. 2014 Oct 1;13(2):305–318. doi: 10.1158/1541-7786.MCR-14-0366

Figure 1.

Figure 1

Microarray analysis of global gene expression profiles of PC-3 and derivative cell lines.

(A) A schematic diagram describing the generation of the PC-3 derivative cell lines using the in vitro transendothelial migration model or the in vivo murine metastatic colonization model. The relationship between the parental PC-3 cell line and all derivative cell lines is depicted. Derivative cell lines selected for gene expression microarray analysis are indicated by boxes. (B) Principal component analysis (PCA) of global gene expression profiles of PC-3 and derivative cell lines. (C) Gene expression levels of 60 well-known splicing factors. The six splicing factors with significant expression differences between PC-3 and derivative cell lines are highlighted. (D) Realtime qPCR results of six splicing factors. GAPDH was used as the reference gene. Relative gene expression level was normalized to PC-3 cells. Error bar indicates the standard error of the mean of technical triplicates.