Figure 2. Region Effects of all treatments on marrow fat or MF measured by DECT (A) and MRI (B).

The region of each boxplot represents the 1^st and 3^rd quartile range of observations, with a black line at the median. Whisker lines are placed at the 1.5 interquartile range of the lower and upper quartile and outliers are noted with open circles. A. DECT: Regions differed in mean MF at baseline. L3 and L4 were equivalent, and L5 was lower by 4% (p<0.001) and FN higher by 13% (p<0.001) relative to L3 and L4. MF increased over time at all sites measured (p<0.001), with an estimated mean change of 7% from baseline to 12 months for all regions. The degree of change in MF was similar among the four regions (p=0.27). B. MRI: Regions differed in mean MF at baseline. L3 and L4 were equivalent, L5 was higher by 5%, and FN was higher by 32% (p<0.001). MF increased over time at all sites measured (p<0.002), with an estimated mean change of 15% from baseline to 12 months for L3–L5. In contrast to DECT, the increase in FN MF was approximately half the increase of L3–L5 (p=0.025).