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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Bone. 2014 Dec 20;0:90–97. doi: 10.1016/j.bone.2014.12.014

Figure 3. Absolute Percent Change in L4 and L5 Marrow Fat by Treatment.

Figure 3

A & B: Based on dual energy computed tomography (DECT) imaging in 15 subjects from 0 to 12 months, L4 MF increased by 9% after radiation, 9% after chemotherapy, and 4% after oophorectomy (p<0.032). The increase in MF was larger for chemotherapy and radiation relative to oophorectomy (interaction p=0.004). From 0 to 12 months, L5 MF increased by 17% with radiation, 8% with chemotherapy and 4% with oophorectomy (p<0.032). The change varied based on treatment (time × treatment interaction p<0.001). C & D: By water- fat MRI imaging, L4 and L5 MF increased from 0 to 12 months. The change varied based on treatment (time × treatment interaction p<0.001). L4 MF increased by 19% after radiation, by 24% after chemotherapy, and by 6% after oophorectomy. Likewise, L5 MF by WF-MRI increased from 0 to 12 months. L5 MF increased by 32% after radiation, by 18% after chemotherapy, and by 6% after oophorectomy.