Table 3.

Summary of hierarchical regression analysis for variables predicting brain volumes in the MRI subsample (N = 703)

	Outcome measure (brain volumes)
Predictor		B	SE (B)	β	Predictor	B	SE (B)	β
CES-D score	Total brain volume	1.033	2.023	0.018	CES-D score	−0.729	1.975	−0.013
Reading		12.492	3.419	0.131***	Education	2.126	0.815	0.107**
CES-D × reading		3.811	2.072	0.065	CES-D × education	−0.329	0.405	−0.028
R2		0.26			R2	0.25
CES-D score	WMH volume	0.039	0.021	0.076	CES-D score	0.031	0.021	0.059
Reading		−0.041	0.036	−0.047	Education	0.009	0.008	0.052
CES-D × reading		0.000	0.022	0.001	CES-D × education	0.002	0.004	0.021
R2		0.049			R2	0.04
CES-D score	Total hippocampal volume	−0.002	0.017	−0.004	CES-D score	−0.013	0.017	−0.031
Reading		0.068	0.029	0.097**	Education	0.009	0.007	0.058
CES-D × reading		−0.016	0.017	−0.036	CES-D × education	−0.005	0.003	−0.052
R2		0.062			R2	0.06

Note: All analyses were controlled for age, gender, and race. Reading, education, and CES-D scores were centered at their means. CES-D, Center for Epidemiologic Studies Depression Scale; WMH, white matter hyperintensities; MRI, magnetic resonance imaging.

^*p < 0.05.

^**p < 0.01.

^***p < 0.001.