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. Author manuscript; available in PMC: 2015 Feb 23.
Published in final edited form as: Angew Chem Int Ed Engl. 2014 Jul 30;53(47):12930–12935. doi: 10.1002/anie.201403936

Figure 6.

Figure 6

Impact of hypoxia on the anticancer activity of erlotinib, L2, and 1a. A) A431 cells were treated with L2, 1a, and erlotinib under normoxic conditions for 72 h. B) A431 (EGFR-overexpressing) and H1975 (overexpression of EGFR with an activating L858R and the secondary T790M resistance mutation) were incubated with 25 μm L2 or 1a under hypoxia or normoxia for 72 h. Cell viability was measured using a MTT-based system. Values given are means ± standard deviation (SD) of one representative experiment performed in triplicate (Statistical analysis: t-test; ***p < 0.001; a: difference between L2 and 1a; b: difference between 1a normoxia and 1a hypoxia).