Table I. Cytochrome P450 (CYP) enzymes involved in metabolism of antipsychotics.

	First-generation	Second-generation
Metabolism	CYP2D6	CYP2D6
	●Chlorpromazine	●Aripiprazole
	●Fluphenazine	○Clozapine
	●Haloperidol	●Iloperidone
	●Perphenazine	○Olanzapine
	●Thioridazine	●Risperidone
	CYP3A4	CYP3A4
	●Haloperidol	●Aripiprazole
	●Loxapine	●Clozapine
	●Pimozide	●Iloperidone
		○Lurasidone
		○Quetiapine
		●Risperidone
		●Ziprasidone
	CYP1A2	CYP1A2
	●Chlorpromazine	●Clozapine
	●Loxapine	●Olanzapine
	●Perphenazine
	●Thioridazine
	●Thiothixene
	●Trifluoperazine
●Primary metabolism
○Secondary metabolism