Table 2.
Multivariate analysis of clinicopathologic factors and occurrence of SLN sentinel lymph node metastasis in patients with a preoperative (N = 624) diagnosis of DCIS or MIC
| Characteristic | Positive SLN (N=40) N (%) |
Negative SLN (N=584) N (%) |
OR (95% CI)* |
P value |
|---|---|---|---|---|
| Age (y) | ||||
| >=50 | 19 (4.8) | 377 (95.2) | Referent | |
| <50 | 21 (9.2) | 207 (90.8) | 1.4 (0.6–2.9) | .43 |
| DCIS size (cm) | ||||
| <=2 cm | 3 (0.1) | 306 (99.1) | Referent | |
| 2–5 cm | 12 (6.9) | 163 (93.1) | 6.8 (1.8–25.2) | .004 |
| >5 cm | 25 (17.9) | 115 (82.1) | 21.9 (6.3–76.7) | <.0001 |
| Method of preoperative diagnosis | ||||
| Excisional biopsy | 2 (1.1) | 186 (98.9) | Referent | |
| Core biopsy | 38 (8.7) | 398 (91.3) | 3.9 (0.9–17.5) | .08 |
| Final histologic type | ||||
| DCIS | 6 (1.6) | 38(98.4) | Referent | |
| MIC | 3 (3.4) | 86 (96.6) | 3.2 (0.8–13.6) | .11 |
| Invasive cancer | 31 (20.8) | 118 (79.2) | 16.9 (6.7–42.7) | <.0001 |
DCIS: carcinoma in situ; MIC: microinvasive breast cancer; SLN: sentinel lymph node; OR: odds ratio; CI: confidence interval.
*
OR and 95% CI values were obtained from multivariate analysis with all variables significant in univariate analysis fitted simultaneously.