Table 3.
Univariate analysis of clinicopathologic factors and occurrence of SLN sentinel lymph node metastasis in patients with a final (N = 475) diagnosis of DCIS or MIC
| Characteristic | Positive SLN (N=9) N (%) |
Negative SLN (N=486) N (%) |
OR (95% CI) |
P value |
|---|---|---|---|---|
| Age (y) | ||||
| >=50 | 3 (1.0) | 319 (99.0) | Referent | |
| <50 | 6 (3.5) | 167 (96.5) | 3.6 (0.9–14.9) | .07 |
| Race | ||||
| White | 6 (1.8) | 343 (98.2) | Referent | |
| Other | 3 (2.3) | 143 (97.7) | 1.3 (0.3–5.2) | .73 |
| Tumor location | ||||
| Outer quadrants | 3 (1.3) | 240 (98.7) | Referent | |
| Other quadrants | 6 (2.4) | 198 (97.6) | 1.9 (0.5–7.6) | .38 |
| Palpable tumor | ||||
| Yes | 1 (1.0) | 96 (99.0) | Referent | |
| No | 8 (2.2) | 359 (97.8) | 2.1 (0.3–17.3) | .48 |
| Unknown | 0 (0.0) | 6 (100.0) | ||
| DCIS size (cm) | ||||
| <=2 cm | 1 (0.4) | 248 (99.6) | Referent | |
| 2–5 cm | 3 (2.3) | 126 (97.7) | 5.9 (0.6–57.4) | .13 |
| >5 cm | 5 (5.2) | 92 (94.8) | 13.4 (1.6–116.9) | .02 |
| Method of preoperative diagnosis | ||||
| Excisional biopsy | 2 (1.2) | (98.8) | Referent | |
| Core biopsy | 7 (2.3) | (97.7) | 1.9 (0.4–9.4) | .41 |
| Final histologic type | ||||
| DCIS | 6 (1.6) | 398 (98.4) | Referent | |
| MIC | 3 (3.4) | 88 (96.6) | 0.9 (0.1–7.0) | .89 |
| Necrosis | ||||
| Absent | 6 (1.6) | 109 (94.0) | Referent | |
| Present | 3 (3.1) | 475 (93.5) | 0.5 (0.1–2.1) | .35 |
| Type of DCIS | ||||
| Comedo | 2 (1.8) | 112 (98.2) | Referent | |
| Non-comedo | 7 (1.9) | 374 (98.1) | 1.1 (0.2–5.4) | .90 |
| Estrogen receptor status | ||||
| Positive | 4 (1.9) | 213(98.1) | Referent | |
| Negative | 3 (3.8) | 78(96.2) | 2.1 (0.4–9.4) | .35 |
| Unknown | 2 (1.1) | 195(98.9) | ||
| Progesterone receptor status | ||||
| Positive | 3 (1.7) | 182(98.3) | Referent | |
| Negative | 3 (2.8) | 108(97.2) | 1.7 (0.3–8.4) | .54 |
| Unknown | 3 (1.6) | 196(98.4) | ||
| Histologic grade | ||||
| I | 2 (3.9) | 31 (93.9) | Referent | |
| II | 4 (2.2) | 228 (93.4) | 0.6 (0.1–5.1) | .60 |
| III | 4 (1.5) | 325 (93.7) | 0.4 (0.04–3.6) | .40 |
DCIS: carcinoma in situ; MIC: microinvasive breast cancer; SLN: sentinel lymph node; OR: odds ratio; CI: confidence interval.