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. Author manuscript; available in PMC: 2015 Feb 23.
Published in final edited form as: Trends Cardiovasc Med. 2011 Jan;21(1):33–36. doi: 10.1016/j.tcm.2012.02.001

Figure 3. Effect of the αIIbβ3 inhibitor eptifibatide on thrombus formation.

Figure 3

Representative photomicrographs evaluating the in vivo efficacy of eptifibatide in preventing (A) mouse versus (B) human platelet-mediated thrombosis in wild type (WT) or VWF R1326H mutant mice, respectively. Eptifibatide was administered as per ACC/AHA guidelines (Kushner et al. 2009): 180 µg/kg intravenous bolus followed by a continuous infusion of 2 µg/kg/min. Thrombus formation was induced by laser injury to arterioles contained within the microcirculation of the cremaster muscle. Data represent the mean ± SEM