Table 5.
Summary of in vitro study of antihyperglycemic activities of PCA.
Model | Model/method | PCA concentration | Major finding | Interpretation | Reference |
---|---|---|---|---|---|
Human omental adipocytes and murine adipocyte 3T3-L1 cells | oxLDL-induced insulin resistance | 100 μM | (i) PCA increased glucose uptake (ii) PCA increased GLUT4 translocation (iii) PCA increased PPARγ activity (iv) PCA increased adiponectin |
PCA exerted an insulin-like activity in adipocytes by increasing PPARγ activation | [45] |