Table 3.

Univariate and multivariate analyses of prognostic factors in the training cohort.

Prognostic factor	Overall survival						Disease-free survival
	Univariate			Multivariate			Univariate			Multivariate
	HR	95% CI	P value	HR	95% CI	Pvalue	HR	95% CI	P value	HR	95% CI	P value
Patient factors
Male gender	1.726	0.895–3.332	0.104				1.635	0.952–2.806	0.075
Age	1.021	1.002–1.040	0.027	1.015	0.996–1.036	0.126	1.012	0.996–1.029	0.134
Hepatitis B	0.888	0.493–1.597	0.691				0.953	0.571–1.591	0.855
Hepatitis C	1.353	0.495–3.699	0.556				1.401	0.614–3.198	0.423
Cirrhosis	1.921	1.229–3.002	0.004	1.901	1.194–3.028	0.007	1.430	0.991–2.063	0.056
Tumour factors
Tumour size (cm)	1.006	1.000–1.011	0.034				1.005	1.000–1.010	0.034
Histological grade	4.125	1.673–10.171	0.002	1.136	0.752–1.717	0.545	3.285	1.666–6.480	0.001	1.107	0.780–1.570	0.570
Multiple tumours	3.120	2.021–4.816	<0.001				2.885	1.965–4.236	<0.001
Vascular invasion	4.371	2.862–6.676	<0.001				3.159	2.181–4.576	<0.001
AJCC stage	2.657	2.079–3.395	<0.001	2.265	1.719–2.985	<0.001	2.400	1.937–2.972	<0.001	2.077	1.623–2.658	<0.001
BCLC stage	1.938	1.569–2.393	<0.001				1.859	1.540–2.243	<0.001
CLIP score	1.773	1.458–2.156	<0.001				1.790	1.500–2.136	<0.001
CUPI score	2.047	1.130–3.707	0.018				2.266	1.341–3.830	0.002
JIS score	2.142	1.762–2.604	<0.001				1.883	1.564–2.268	<0.001
Blood parameters
AFP ≥500 μg/L	1.893	1.244–2.883	0.003	1.465	0.916–2.341	0.111	1.985	1.384–2.847	<0.001	1.422	0.955–2.118	0.083
AAPR (>0.68/0.23–0.68/<0.23)	3.347	1.966–5.699	<0.001	2.357	1.354–4.102	0.002	2.464	1.550–3.916	<0.001	1.852	1.158–2.964	0.010
MELD	2.951	1.419–6.136	0.004	0.999	0.894–1.119	0.875	1.197	1.086–1.321	<0.001	1.068	0.964–1.184	0.208

Tumour size, multiplicity, vascular invasion, and staging systems with lower c-index than AJCC were excluded in the multivariate analyses to minimize multicollinearity.