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. 2015 Feb 24;46:15. doi: 10.1186/s13567-015-0153-8

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© Manjunath et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Protein–protein interaction network for differentially expressed highly connected genes (DEHCNet). Genes that were upregulated and downregulated were shown in green and red colors, respectively, with the gradient showing the extent of expression (log₂(fold change) ranging from 1.5 to 5.15 for upregulated and −1.5 to −3.39 for downregulated genes). The diameter of the node represents the connectivity/degree of the node among the 985 differentially expressed genes. Self loops have been removed. CARD11, IRF3, RAC1, UBA2, CLINT1, HERC2, TMEM66, DCAF8, BTG1, MAT2A, HYOU1, POLA1, CD44, ID2 and RB1CC1 genes had no connectivity with other DEHC genes.