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. 2015 Feb 24;46:15. doi: 10.1186/s13567-015-0153-8

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© Manjunath et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Transcription factors binding upstream of DEHC genes. A) Heatmap showing the binding sites of 41 Bos taurus orthologs upstream of DEHC genes. B) Motif alignments of each of the predicted 12 motifs with their corresponding known binding motifs for TFs, which were also found to be differentially expressed. The bottom sequences are the predicted motifs and the top sequences are TF-binding consensus sequences matching the motifs. Binding specificity of TFs is shown for all the motifs. Genes encoding the TFs that are upregulated are shown in green colour and that are downregulated are shown in red colour.