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. 2015 Feb 19;8:11. doi: 10.1186/s13041-015-0102-5

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© Chen et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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TRPM7 protein expression in the cortex of HI mice and TUNEL staining of mouse brain slices. A, western blotting results of TRPM7 protein expression in the injured hemisphere (ipsilateral) and uninjured contralateral hemisphere 24 hours after HI. TRPM7 protein expression level is higher in injured hemisphere than the contralateral hemisphere (*, p < 0.05, n = 4). B, TUNEL staining was carried out 3 days after HI and images were viewed using fluorescence microscopy. Left panel shows the representative images of TUNEL staining. Red fluorescence in TUNEL-positive cells indicates apoptosis. Blue fluorescence is DAPI staining for nucleus. Scale bar represents 10 μm. Right panel shows the mouse brain coronal sections. C, Quantitative analysis of TUNEL-positive cells showed that pre-treatment with carvacrol (50 mg/kg) reduced the number of TUNEL positive cells (*, p < 0.05 compared with sham group. #, p < 0.05 compared with vehicle group, n = 3, One-way ANOVA followed by Newman-Keuls test).