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. Author manuscript; available in PMC: 2015 Feb 23.
Published in final edited form as: J Am Chem Soc. 2012 Apr 5;134(15):6617–6624. doi: 10.1021/ja2104075

Figure 1.

Figure 1

Scheme for SHAPE chemistry emphasizing that reactivity is governed primarily by the ability of a nucleotide to adopt a conformation that enhances the reactivity of the 2′-hydroxyl group towards SHAPE electrophiles.