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The diagnostic performance of the best cutoff values of AFP and MDK for discriminating HCC group from LC group.
| Cutoff value | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | P | |
|---|---|---|---|---|---|---|---|---|
| MDK | 0.387 | 0.941 (0.890–0.992) | 92.5 | 83.3 | 88 | 89.2 | 88.5 | 0.001 |
|
| ||||||||
| AFP | 88.5 | 0.671 (0.546–0.796) | 40 | 96.7 | 94.1 | 54.7 | 64.2 | 0.015 |
MDK: midkine; AFP: alpha-fetoprotein; AUC; area under the curve; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value.
