FIGURE 2.

Multi-level contribution of microRNA to synaptic plasticity. MicroRNA likely influence the translation of multiple mRNA important in specific aspects of synaptic plasticity including neurotransmitter release, AMPA and NMDA receptor subunit levels, dendritic spine size, and gene transcription. APT1, acyl-protein thioesterase 1; ARC, activity-related cytoskeleton-associated protein; BDNF, brain-derived neurotrophic factor; CaMKIIγ, calcium/calmodulin-dependent protein kinase II gamma; CREB, cAMP response element-binding protein; EGR1, early growth response 1; GluA1, glutamate receptor, ionotropic, AMPA 1; GluA2, glutamate receptor, ionotropic, AMPA 2; GluN2A, glutamate receptor, ionotropic, NMDA 2A; GluN2B, glutamate receptor, ionotropic, NMDA 2B; LIMK1, LIM domain kinase 1; MECP2, methyl CpG binding protein 2; MEF2, myocyte enhancer factor-2; NRP2, neurophilin 2; PTEN, phosphatase and tensin homolog; PUM2, pumilio homolog 2; SERCA, sarco/endoplasmic reticulum Ca²⁺ ATPase; SIRT1, sirtuin 1; STX1A, syntaxin 1a; SV2A, synaptic vesicle glycoprotein 2A; SYN1, synapsin I; SYN2, synapsin II; SYT1, synaptotagmin I.