Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 23;9:52. doi: 10.3389/fncel.2015.00052

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Tarang, Doi, Gurumurthy, Harms, Quadros and Rocha-Sanchez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Reversible in vivo DN-CBRb transgene regulation. P10 DN-CBRb⁺/ROSA-CAG-rtTA⁺ mice were fed with Dox in drinking water for 10 consecutive days. Untreated animals of the same genotype were used as control group (Group 1; -Dox). At the end of Dox treatment animals were euthanized either immediately (Group 2; +Dox) or 5 days after Dox withdraw (Group 3; ±Dox). Supporting the reversibility of the system, RB1 levels were visibly decreased on group 2. Nevertheless, cochleae collected 5 days after Dox withdraw showed RB1 levels, which were comparable to those of the control group.