Table 2.

Summary of the proposed RANO response criteria.

Criterion	CR	PR	SD	PD
T1 gadolinium enhancing disease	None	≥50% ↓	<50% ↓but <25% ↑	≥25% ↑a
T2/FLAIR	Stable or ↓	Stable or ↓	Stable or ↓	↑a
New lesion	None	None	None	Presenta
Corticosteroids	None	Stable or ↓	Stable or ↓	NAb
Clinical status	Stable or ↑	Stable or ↑	Stable or ↑	↓a
Requirement for response	All	All	All	Anya

RANO, response assessment in neuro-oncology; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; FLAIR, fluid-attenuated inversion recovery; NA, not applicable.

^aProgression occurs when this criterion is present.

^bIncrease in corticosteroids alone will not be taken into account in determining progression in the absence of persistent clinical deterioration.

Reprinted with permission from Ref. (6), License Number 3484960750851.