Figure 2.

Progesterone-modulated functional connectivity in bilateral dorsolateral prefrontal cortex and hippocampus. The whole brain Eigenvector Centrality Mapping (EC) analysis reveals a significant correlation of progesterone with bilateral dorsolateral prefrontal cortex (DLPFC) (p < 0.001 unc.; left panel). In the seed based analysis, these progesterone-modulated intrinsic connectivity-changes in right and left DLPFC were found to connect with bilateral hippocampus (right panel). For the left DLPFC (top panel), connectivity-changes to bilateral hippocampus were observed at a threshold of p < 0.005 (signal change depicted in red). The right DLPFC also showed progesterone-modulated connectivity with bilateral hippocampus modulated by progesterone at both thresholds: p < 0.001 (unc.; signal change depicted in yellow) and p < 0.005 (unc.; signal change depicted in red).