Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 23;6:9. doi: 10.3389/fendo.2015.00009

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Neal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

(A) The glomerular filtration barrier (GFB) with the disposition of membrane associated domains in foot processes (FPs). Diagram shows three FPs with apical domain (AD), basal domain (BD), and slit diaphragm domains (SDD) outlined. The apical actin bundles are shown, other actin networks cortical actin (sub-plasmalemmal actin) surrounding the actin bundle are attached to the various membrane domains. The cortical actin meshwork in BD and SDD is thicker than AD. ECC, endothelial cell cytoplasm; F, fenestration; G, glycocalyx. (B) Interdigitating foot process (FP) pattern in health (left) and after effacement in disease (right). The dashed line in FP marks the boundary of the actin bundles. MT – microtubules in the major processes. Actin bundles and cortical actin either reduce to a diffuse band of actin after effacement or disperse with effacement.