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. Author manuscript; available in PMC: 2015 Feb 23.
Published in final edited form as: Nitric Oxide. 2012 Mar 30;26(4):241–250. doi: 10.1016/j.niox.2012.03.007

Fig. 4.

Fig. 4

Nitrite therapy improves post-CA mitochondrial function. Respiratory control ratios (RCR) were calculated using the complex I substrates malate and pyruvate (A and C) or the complex II substrate succinate (B and D). Mitochondria were isolated from hippocampus (A and B) or the remaining whole brain (C and D) of non-arrested shams or 1 h post-arrest animals treated with nitrite or placebo (n = 4 each group). Nitrite therapy showed trends (p = 0.05–0.15) towards improved function in nearly all groups assessed except complex II dependent function in whole brain (D) where all results were similar. These effects appeared more prominent in hippocampus (A and B) than the remainder of brain (C and D).