Table III. Conventional Echocardiographic Measurements.
Age (weeks) | |||||
---|---|---|---|---|---|
|
|||||
3 | 5 | 7 | 11 | P-value | |
Morphometric parameters | |||||
Body weight (g) | 7.8 ± 0.3 | 18.3 ± 1.2* | 20.7 ± 1.0* | 24.5 ± 2.0* | <0.01 |
Tibia length (mm) | 11.3 ± 0.1 | 14.8 ± 0.2* | 16.1 ± 0.1* | 16.1 ± 0.9* | <0.01 |
LV mass (mg) (necropsy) | 27 ± 1 | 61 ± 4* | 72 ± 6* | 84 ± 7* | <0.01 |
LV mass (mg) (ECHO†) | 28.4 ± 5.9 | 41.9 ± 6.8 | 73.7 ± 12.7 | 79.8 ± 18.2 | <0.01 |
Conventional echocardiographic measurements | |||||
Ejection fraction (%) | 75 ± 1 | 70 ± 3 | 60 ± 1* | 61 ± 2* | <0.01 |
Fractional shortening (%) | 44 ± 1 | 39 ± 2 | 33 ± 2* | 34 ± 2* | <0.01 |
LVEDD (mm) | 2.7 ± 0.1 | 3.5 ± 0.1* | 4.3 ± 0.1* | 4.0 ± 0.2* | <0.01 |
LVESD (mm) | 1.5 ± 0.04 | 2.1 ± 0.10* | 2.9 ± 0.1* | 2.7 ± 0.2* | <0.01 |
LVPWd (mm) | 0.4 ± 0.04 | 0.5 ± 0.04 | 0.6 ± 0.03* | 0.6 ± 0.02* | <0.01 |
LV = left ventricle; LVEDD = left ventricle end-diastolic dimension; LVESD = left ventricular end-systolic dimension; LVPWd = left ventricular posterior wall thickness.
P < 0.01 as compared to 3 weeks.
LV mass calculated from echocardiographic measurements.