TABLE 1.
Pox lesion counts in mice that were infected with IHD-J-Luc VACV and treated with BCV
| Treatment regimen | Survival (%) | Pox lesion count by day postinfection (mean ± SD)a |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 14 | 21 | ||
| Days 1, 3, and 5 | |||||||||||
| Vehicle | 0 | 1.4 ± 1.6 | 4.0 ± 2.8 | 6.2 ± 2.6 | 6.7 ± 2.2 | NA | NA | NA | NA | NA | NA |
| BCV | |||||||||||
| 2.5 mg/kg | 17 | 0.2 ± 0.4 | 1.7 ± 1.2 | 2.7 ± 1.4** | 5.2 ± 2.5 | 4.2 ± 2.1 | 5.3 ± 2.3 | 2.8 ± 2.7 | 1.6 ± 1.3 | 1.0 | 0.0 |
| 5 mg/kg | 100 | 0.7 ± 0.8 | 2.2 ± 2.4 | 3.7 ± 2.3* | 4.2 ± 2.3* | 5.0 ± 4.2 | 3.3 ± 2.6 | 3.0 ± 2.6 | 2.5 ± 2.4 | 0.5 ± 1.2 | 0 ± 0 |
| 20 mg/kg | 100 | 0 ± 0 | 0 ± 0* | 0 ± 0** | 0 ± 0** | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
| Days 2, 4, and 6 | |||||||||||
| Vehicle | 0 | 1.2 ± 0.7 | 5.5 ± 2.2 | 7.5 ± 2.5 | 7.5 ± 1.1 | NA | NA | NA | NA | NA | NA |
| BCV | |||||||||||
| 5 mg/kg | 33 | 3.7 ± 2.0 | 6.8 ± 2.5 | 8.7 ± 1.9 | 9.2 ± 0.9 | 8.8 ± 3.7 | 6.0 ± 3.2 | 5.3 ± 4.6 | 2.5 ± 1.8 | 0 ± 0 | 0 ± 0 |
| 20 mg/kg | 100 | 2.3 ± 0.9 | 2.7 ± 1.2* | 4.8 ± 0.7* | 4.8 ± 1.3** | 2.2 ± 1.1 | 1.5 ± 0.5 | 1.7 ± 1.4 | 0.2 ± 0.4 | 0.2 ± 0.4 | 0 ± 0 |
a
Mice were infected at day 0. Pox lesions on mouse tails were counted using dorsal images of individual mice and were used to calculate average pox numbers ± SD per surviving animal on each day shown. Asterisks denote significant differences between vehicle- and BCV-treated groups of mice in mean daily pox counts. *, P ≤ 0.05; **, P ≤ 0.001. NA, not applicable.