TABLE 3.

AUCs for nude mice infected with IHD-J-Luc VACV and treated with a short or extended course of 20 mg/kg BCV

Organ	Mean AUC by day and regimen (log10 photons/s × day)a
	Day 6		Day 21
	Vehicle	BCV short courseb	BCV short course	BCV extended coursec
Nasal cavity	42.3 ± 1.4	41.4 ± 1.1	174.3 ± 1.6	162.1 ± 3.5*
Lungs	32.2 ± 1	27.3 ± 1.5†	120.0 ± 3.4	104.2 ± 1.8**
Liver	36.4 ± 2.3	27.8 ± 2.5†	115.2 ± 3.0	99.8 ± 1.8**
Spleen	35.2 ± 2.7	26.2 ± 3.1†	109.8 ± 2.0	92.0 ± 4.3*

^aMean AUCs (log₁₀ photons/s × day) ± SD were calculated for fluxes in mice for days 1 to 6 for the vehicle-treated group and the BCV short course group and for days 1 to 21 for the BCV short course and extended course. Significant differences in mean AUCs between the groups receiving vehicle and the short course of BCV treatment are indicated as follows: †, P ≤ 0.001. Significant differences in mean AUCs between the groups receiving the short course and extended course of BCV treatment are indicated as follows *, P ≤ 0.05; **, P ≤ 0.001. Significance was determined with a two-sample t test.

^bTreatment on days 1, 3, and 5.

^cTreatment on days 1, 3, 5, 7, 10, 14, 17, 21, and 24.