TABLE 1.
Binding avidities for MAb 1.12a
| Isolate | kon (1/mol·s) | koff (1/s) | KD (M) |
|---|---|---|---|
| A/Puerto Rico/8/1934(H1N1) | 4.24 × 105 | ≤5.0 × 10−5 | ≤1.2 × 10−10 |
| A/Moscow/10/1999(H3N2) | 2.95 × 104 | ≤5.0 × 10−5 | ≤1.7 × 10−9 |
| A/Duck/Czechoslovakia/1956(H4N6) | 5.81 × 105 | 2.9 × 10−4 | 5.0 × 10−10 |
| A/Vietnam/1203/2004(H5N1) | 1.06 × 106 | ≤5.0 × 10−5 | ≤4.7 × 10−11 |
| A/Duck/Alberta/60/1976(H12N5) | 1.08 × 105 | 6.6 × 10−5 | 6.1 × 10−10 |
a
hMAb 1.12 was immobilized on an anti-Fc-coated CM5 chip before binding of soluble recombinant HA was assessed, and binding constants were calculated on a Biacore instrument.