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Vaccine effects on SARS-CoV lung pathology and virus titers. Groups of immunized mice (n = 5 for each time point) were sacrificed on days 3 and 6 postchallenge and lungs harvested. Shown are lung histology scores (A and B), lung weights (C and D), lung virus titers (limit of detection, 0.75) (E and F), and SP-specific lung IgG titers (G and H). All values are means ± SEM.
