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. 2015 Feb 10;6(1):e02445-14. doi: 10.1128/mBio.02445-14

FIG 6 .

FIG 6 

Metabolic reconstruction and analysis of S. neurona based on iCS382. (A) Overlap in enzyme predictions for genes from S. neurona, T. gondii, and P. falciparum. (B) Species-specific differences in growth rates of single-reaction knockouts. Only reactions that show a growth rate difference of 20% between T. gondii and S. neurona are shown. (C) Impact of deletion of reactions involved in glycolysis and the TCA cycle on S. neurona growth under conditions of exclusive glucose or sucrose uptake. d-glc-6-P, d-glucose-6-phosphate; G6PI, glucose-6-phosphate isomerase; d-frc-6-P, d-fructose-6-phosphate; DF6P1P, diphosphate-fructose-6-phosphate 1-phosphotransferase; FBA, fructose-bisphosphate aldolase; PK, pyruvate kinase; Cyt, cytosol; Mito, mitochondrion; PC, pyruvate carboxylase; CS, citrate synthase; AH, aconitate hydratase; ID, isocitrate dehydrogenase (NADP+); OD, oxoglutarate dehydrogenase (succinyl-transferring); DS, dihydrolipoyllysine-residue succinyltransferase; SL, succinate-CoA ligase (ADP-forming); SD, succinate dehydrogenase (ubiquinone); FH, fumarate hydratase; MD, malate dehydrogenase; frc, fructose. (D) Relationship between fructose, glucose, and sucrose import and growth.