FIG. 1.

Proportions of patients with worsening vision by EDSS progression status over 2 years. Using 7-letter criterion for clinically meaningful visual change, a significantly greater number of patients with EDSS progression had worsening in HCVA compared with those with no EDSS progression. Notably, there were no significant differences in LCVA worsening between patients with and without EDSS progression. P values are from McNemar's test. EDSS, Expanded Disability Status Scale; HCVA, high-contrast visual acuity; LCVA, low-contrast visual acuity; VFT, visual function testing.