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. 2014 Dec 9;11(4):2465–2470. doi: 10.3892/mmr.2014.3068

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Chloride channel blocker tamoxifen prevents cisplatin-induced decreases in cell volume of MG-63 human osteosarcoma cells. (A) Time-dependent changes in MG-63 cell volume following incubation in isotonic bath solutions, with or without cisplatin (CDDP; 2 μg/ml) and tamoxifen (20 μM) treatment. (B) Final cell volumes following treatment for 360 min with different bath solutions. Cell volume analysis was standardized to that of the control group. The data represent the mean ± standard error of 23–32 imaged cells. ^**P<0.01, vs. the control.